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Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription

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NIAID Data Ecosystem2026-03-12 收录
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We performed RNAseq experiments to examine genome-wide transcriptional changes in PFC of shRNA-Kmt5b KD mice compared to GFP injected control mice. mRNA via RNAseq analysis of three 6-8 week old shRNA-Kmt5b-injected KD mice (C57BL/6 x C3H) , and two 6-8 week old GFP-injected control mice (C57BL/6 x C3H) PFC tissue were compared.

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2021-08-19
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