Identification of putative ROREs in the genes displayed by the micro-array analysis.

Regulatory regions (600–1100 bp promoters or intragenic regions) of ten human genes displayed by our over-expression experiments were extracted from sequence databases (Genomatix, UCSC, Genbank) and analyzed for the presence of sequences close to the RORE consensus ((A/T rich)6PuGGTCA). We found that regulatory regions of nine human genes out of ten contain one or two putative ROREs. The gene symbols are given in column 1. Sequences containing the putative ROREs (in bold) are in column 2. Positions of these sequences relatively to the transcriptional start sites (TSS; +1) in the human promoters or positions in the intragenic regions are in column 3. Some promoters contain three possible TSSs (PLG, G6PC, NR1D2, MLLT7, ADIPOQ). In these cases, the positions of the sequences are relative to the downstream TSS. Species in which the RORE is totally or partially conserved are given in column 4 (the RORE sequences found conserved in the species available in the databases are shown in Supporting Information S3). No RORE has been found in the human SMOC1 promoter. The human LPA promoter could not be analyzed because it was not referenced in the Genomatix program.