Autophosphorylation and activation of CAMK2
收藏reactome.org2025-01-16 收录
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Binding of CaM to CAMK2 displaces the autoinhibitory loop from the active site and allows CAMK2 to autophosphorylate T286, resulting in CAMK2 activation (reveiwed in Stratton et al, 2013).
钙调蛋白(CaM)与钙/钙调蛋白激酶II型(CAMK2)的结合,使自抑制环从活性位点移位,进而允许CAMK2在T286位点进行自磷酸化,导致CAMK2的激活(参见Stratton等,2013年的综述)。
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