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CAPN2: A Target Enabling Package

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NIAID Data Ecosystem2026-05-02 收录
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https://zenodo.org/record/5903022
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CAPN2 mediates neurodegenerative effect through cleavage of a range of proteins linked to tau hyperphosphorylation (GSK-3β), higher levels of Aβ (NCX3), or poor memory (CPEB3).  Inhibiting calpain-2 might reduce cleavage of these proteins and reverse its neurodegenerative effect. This aim of this TEP is to produce reagents to allow for further analysis of CAPN2 as a potential target for AD treatment.
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2025-03-10
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