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Ponatinib-induced cardiotoxicity is driven by S100A8/A9-NLRP3-IL-1ß signaling mediated excessive inflammation

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NIAID Data Ecosystem2026-03-14 收录
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To delineate the underlying molecular mechanisms of ponatinib-induced cardiotoxicity, we used we a comorbitity cardiotoxicity mouse model (high fat-fed ApoE-/- mice) treated for two weeks with placebo/ or Ponatinib We then performed gene expression profiling analysis on left ventricular tissues from the two mouse groups Overall design: Comparative gene expression profiling analysis of RNA-seq data for Placebo or Ponatinib-treated high fat-fed ApoE-/- mice

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2023-02-09
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