This study was to develop a faithful pre-clinical MDS patient-derived xenotransplantation model in cytokine-humanized immunodeficient "MISTRG" mice. We performed targeted genome sequencing on bone mar

NIAID Data Ecosystem70

Gene expression profile of HSPC with cell-intrinsic innate immune signaling activation after LPS treatment

造血干细胞基因表达

骨髓增生异常综合征

The underlying mechanisms responsible for the competitive advantage of MDS HSPC in an inflammatory milieu remains poorly defined. Here, we show that MDS HPSC are protected from low-grade chronic infla

NIAID Data Ecosystem50

Supplementary Material for: Copper Deficiency Mimicking Myelodysplastic Syndrome: Zinc Supplementation in the Setting of COVID-19

铜缺乏症

骨髓增生异常综合征

While copper deficiency is rare, it can have serious consequences, including pancytopenia and neuropathy. This treatable vitamin deficiency can present very similarly to myelodysplastic syndrome (MDS)

DataCite Commons2023-07-22 更新80

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

骨髓增生异常综合征

SF3B1突变剪接异常

SF3B1 is the most frequently mutated RNA splicing factor in cancer, including in ~25% of myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly associated with ringed siderobla

NIAID Data Ecosystem50

Targeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome

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