Transcriptome-wide analysis of imprinted gene expression in cloned mice

Somatic cell nuclear transfer (SCNT) can produce viable individuals, but the success rate is very low. While many works hypothesized that defects in SCNT-derived animals are caused by abnormal imprinted gene expression, few non-random loss of imprinting have been found. In this study, we performed a transcriptome-wide analysis of imprinted gene expression in cloned mouse placenta and brain, and found that many imprinted genes showed abnormal expression in cloned mice.