Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
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https://zenodo.org/doi/10.5281/zenodo.20433104
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资源简介：
These files contain the data described in Broadaway (2024), AJHG, PMID: 39173627.
Version 2 corrects an annotation-join issue in the previously uploaded files. A small number of signals from 5 genes were unintentionally excluded from Version 1 during file generation. Additionally, Version 1 files used formatting that differed from the Mohlke Lab website release. This corrected release restores the excluded genes and harmonizes the Zenodo files with the website release.
Marginal eQTL summary stats:
Column label
Description
Entrez
Entrez ID
Variant
Chromosome_position_NonEffectAllele_EffectAllele
CHR
Chromosome
POS
Position (hg19)
NEA
Non-effect allele
EA
Effect allele
EAF
Effect allele frequency
Beta
Effect size of association between variant and gene
SE
Standard error
PVAL
p-value of association between variant and gene
N
Sample size for variant
Studies
Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161)
GeneSymbol
Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110)
ENSG
Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110)
Gene_Biotype
Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110)
Files for download:
Description
Marginal eQTL full summary statistics – all results by chromosome
Filename
Liver_eQTL_Meta_Marginal_20240530.tar.gz
Size
1.9 GB
Date
5/30/2024
Isolated eQTL summary stats (each signal isolated):
Column label
Description
GeneSymbol
Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110)
Entrez
Entrez ID
SignalLead
Lead variant of isolated signal
Variant
Chromosome_position_NonEffectAllele_EffectAllele
NEA
Non-effect allele
EA
Effect allele
EAF
Effect allele frequency
Beta
Effect size of association between variant and gene
SE
Standard error
PVAL
p-value of association between variant and gene
N
Sample size for variant
Studies
Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161)
ENSG
Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110)
Gene_Biotype
Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110)
Files for download:
Liver_eQTL_Meta_Isolated_20240530.tar.gz
Description
Isolated conditional summary statistics for significant signals – all results by chromosome. Only genes for which >1 signal was detected are included in this isolated summary statistics dataset. For single-signal eGenes, refer to the marginal dataset.
Filename
Size
609 MB
Date
5/30/2024
提供机构：
Zenodo
创建时间：
2026-05-28
