ActivinA-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=20e5d4531bb2851563344b3c7f1a6ced
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资源简介：
Robust differentiation of hPGCLCs starting from hESCs is currently hampered by the inherent heterogenous nature of different hESC lines. Here, we show that hESC lines, that were both derived and cultured in the presence of ActA, show high competence to differentiate to PGCLCs, in particular if transiently converted to the 4i-state prior to differentiation. We performed a robust and systematic comparison of isogenic lines and provide an optimized protocol to obtain PGCLCs from hESCs.
提供机构：
Ghent University
创建时间：
2022-02-20
