Methodological quality of included randomized controlled trials.^*

Abbreviations: AFCAPS, Air Force/Texas Coronary Atherosclerosis Prevention Study; ALLHAT-LLT, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial; LIPS, Lesol Intervention Prevention; 4S, Scandinavian Simvastatin Survival Study; HPS, Heart Protection Study; WOSCOPS, West of Scotland Coronary Prevention Study. *Yes, low risk of bias; Unclear, unclear risk of bias; No, high risk of bias. †Follow-up ≥4 years.