Depletion of AUF1 from myeloid cells protects from allergic airway and tumor infiltration and alters pro-angiogenic macrophage polarization by adenosines

Our data demonstrate that in innate immune cells, AUF1 does not act as a generic anti-inflammatory factor but has a rather distinct role in selective macrophage phenotypes. We use a conditional allele for the myeloid deletion of the hnRNPD gene and employ a disease-oriented phenotypic screen to assess the requirement of AUF1 in contexts of innate immune reactivity.