Heterobimetallic Pd–Sn Catalysis: Michael Addition Reaction with C‑, N‑, O‑, and S‑Nucleophiles and in Situ Diagnostics

An efficient Michael addition reaction
of differently substituted
enones with carbon, sulfur, oxygen, and nitrogen nucleophiles has
been achieved by a new heterobimetallic “Pd–Sn”
catalyst system. The nature of the catalytically relevant species
and their interactions with the enone moiety has been examined by
spectroscopy. The effect of ligand and the coordination mode of enone
with “Pd–Sn” heterobimetallic system have been
investigated by kinetics and DFT studies. A straightforward application
of this methodology is shown in the synthesis of 1,4-oxathiepane core.