Results of the parent-of-origin (POO) analysis for the NOD2 variants in Dutch Crohn’s disease trios (n = 111) and replication in German Crohn’s disease trios (n = 598).

P-value (p-α; ß; γ) and odds ratio (OR-α; ß; γ) of the alpha-, beta-, and gamma-terms. P-value of the replication study (p- α; -ß; - γ replication ) of the alpha-, beta-, and gamma-terms. Alpha-term indicates the genomic imprinting effect; Beta-term and gamma-term indicate the maternal effect in case the mother carries respectively two and one risk alleles. Significant associations are in bold.◊Significant after Bonferroni multiple testing correction. P-values displayed in the table are not corrected for multiple testing.*No homozygous mothers are available for beta-term analysis.