mRNA expression profiles of oxygen-induced retinopathy (OIR) mouse retinas after knockdown treatment of lncRNA-MM2P

The purpose of this study is to investigate the mRNA expression profiles of OIR retinas after knockdown treatment of lncRNA-MM2P. We established an OIR model in C57BL/6J mice. The expression of lncRNA-MM2P in the retinas of OIR mice was knocked down by intravitreal injection of self-complementary adeno-associated virus (scAAV). Retinas of four eyes from two OIR mice were collected as one sample. The control group was treated with control scAAV and named as AAV_NC, the knockdown group was treated with knockdown scAAV and named as AAV_sh. The total RNA was extracted from total of eight samples (four samples each group) for RNA sequencing. RNA sequencing of retinas from 17-day old oxygen-induced retinopathy (OIR) C57BL/6J mice which were knocked down of lncRNA-MM2P by scAAV or treated with control scAAV.