Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.
收藏PubMed Central1995-09-12 更新2026-05-02 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC41095/
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资源简介：
Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-09-12
