Correlation of circulating PAI-1 with its hepatic gene expression and liver function.

PAI-1, plasminogen activator inhibitor type 1; mRNA, messenger ribonucleic acid; ALT, alanine transaminase; AST, aspartate transaminase; CI, confidence interval; N, number of values. 3 month-old mice were subjected to trauma and hemorrhage (−48 h) followed by CLP sepsis of medium-severity (17G) at 0 h. In the post-CLP phase, mice with body temperature (BT) <28°C and littermates with BT >36°C were identified (1∶1 ratio) and instantly sacrificed. PAI-1 mRNA expression in the liver and plasma concentrations of total PAI-1, ALT and AST, and were correlated independent of BT and expressed by Spearman’s rank correlation coefficient (ρ).