The results for 100 phenotypes of UKB WES data analysis

RareEffect analysis results This repository contains the summary-level analysis results generated for the manuscript: Rare variant effect estimation and polygenic risk prediction The data were generated using RareEffect from the analysis of UK Biobank whole-exome sequencing (WES) data. Contents 1. Gene-level signed heritability estimates File format: Column Description pheno Phenotype identifier. Continuous traits are represented by UK Biobank field IDs, whereas binary traits are represented by PheCodes obtained through ICD-10 to PheCode mapping. gene Gene symbol. LoF Estimated heritability attributable to predicted loss-of-function (LoF) variants (unsigned). mis Estimated heritability attributable to missense variants (unsigned). syn Estimated heritability attributable to synonymous variants (unsigned). signed_h2 Total gene-level heritability estimate with the estimated effect direction (signed heritability). 2. Variant-level effect size estimates File format: Column Description pheno Phenotype identifier. Continuous traits are represented by UK Biobank field IDs, whereas binary traits are represented by PheCodes obtained through ICD-10 to PheCode mapping. gene Gene symbol. variant Variant identifier. beta Estimated variant effect size produced by RareEffect. PEV Prediction error variance (PEV) of the estimated effect size. Data availability These files contain summary-level analysis results only. Individual-level genotype data, phenotype data, and individual polygenic risk scores are not included. If you use these data, please cite: Nam K, Kho M, Zhou W, Mukherjee B, Lee S. Rare variant effect estimation and polygenic risk prediction. Nature Genetics (2026).