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MCF10A H-Ras RNA-Seq

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81593
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Paired-end sequencing of Vector and H-Ras expressing cell lines: p53-del and WT-p53 We found that activated forms of H-Ras and PIK3CA oncogene lead to repression of p63, a p53 family member. They also lead to induction of EMT, a cancer-related process. Our results suggest that, through Ras regulation of p63, this oncogene can drive mammary epithelial cells towards greater invasive ability. 4 samples analyzed with 3 replicates each, control samples for each H-Ras line are the Vector cell line created at the same time
创建时间:
2019-05-15
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