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资源简介：
PacBio - Class Switch Recombination Junctions - for DNA repair signatures analysis in mouse
应用场景：
创建时间：
2025-09-30
相关数据集
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Mus musculus
ERCC6L2 facilitates deletional antibody class switch recombination.
NIAID Data Ecosystem60
Data_Sheet_1_Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching.pdf
Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy (IgH) locus. During CSR, transcrip
NIAID Data Ecosystem30
Distinct requirements of CHD4 during B cell development and antibody response
Immunoglobulin heavy chain (Igh) class switch recombination (CSR) requires B cell proliferation, germline transcription, AID-instigated generation of DNA double strand breaks and DNA end-joining. How
NIAID Data Ecosystem20
Long-range joining of intra-chromosomal DNA double-strand breaks. Mus musculus
Antibody class switch recombination (CSR) in B lymphocytes joins two DNA double-strand breaks (DSBs) lying 100 to 200 kilobases (kb) apart within switch (S) regions in the immunoglobulin heavy chain l
NIAID Data Ecosystem40
A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination [ChIP-Seq]
Antibody class switch recombination (CSR) requires the ligation of DNA breaks in transcribed and juxtaposed donor and acceptor switch (S) sequences (S-S synapsis) spaced 50-200 kb apart within the imm
NIAID Data Ecosystem30
