Carbendazim induced genomic instability in yeast. Carbendazim induced genomic instability in yeast

Carbendazim (Methyl benzimidazol-2-ylcarbamate; MBC) is an antimitotic drug used for broad-spectrum fungicide, antineoplastic and mutagen in microbial breeding. Using a customized SNP microarray technology, this work revealed the effect of MBC on genomic instability (loss of heterozygosity, chromosomal rearrangements and aneuploidy) in the diploid yeast Saccharomyces cerevisiae JSC25. Overall design: By SNP microarrays specific for chromosome 4, we analyzed 40 JSC25-derived mutants treated with MBC to uncover the details of MBC-induced genomic instability.