Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause for cancer related deaths among women in USA. Most patients have metastatic disease at the time of diagnosis and this

NIAID Data Ecosystem40

CBX8 together with SET facilitates ovarian carcinoma growth and metastasis by suppressing the transcription of SUSD2. CBX8 together with SET facilitates ovarian carcinoma growth and metastasis by suppressing the transcription of SUSD2

卵巢癌转移机制

转录调控与肿瘤抑制

CBX8 promotes cell proliferation and migration through downregulating the expression of SUSD2.The mRNAs from SKOV3 cells expressing control shRNAs or CBX8 shRNAs were extracted and subjected to RNA-se

NIAID Data Ecosystem40

Stanniocalcin 1 promotes metastasis by enhancing lipid metabolism via FOXC2/ITGB6 signaling axis in ovarian cancer. Stanniocalcin 1 promotes metastasis by enhancing lipid metabolism via FOXC2/ITGB6 signaling axis in ovarian cancer

卵巢癌转移机制

脂质代谢调控

Stanniocalcin 1 (STC1) plays an integral role in the metastasis of ovarian cancer. However, the functional role of STC1 in lipid metabolism is not fully understood. Single-cell sequencing assays verif

NIAID Data Ecosystem70

Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model

卵巢癌转移机制

细胞-基质粘附

High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid metastasis throughout the peritoneal cavity. Prev

NIAID Data Ecosystem40

Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer

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