Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse kidney after a single 20 μg/kg intravenous dose.
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In kidney, 111In-DOTA-targeted mIFNα2 had a terminal half-life of 75.4 hours, Cmax of 327 ng/g, Tmax of 2 hours, an AUC(0-∞) of 34,795 hr*ng/g, an AUC(0–12) of 3,551 hr*ng/mL and an AUC(0–24) of 6,899 hr*ng/mL. 111In-DOTA-non-targeted mIFNα2 had a terminal half-life of 84.1 hours, Cmax of 736 ng/g, Tmax of 12 hours, an AUC(0-∞), an AUC(0–12) of 7,776 hr*ng/mL and an AUC(0–24) of 15,874 hr*ng/mL of 91,128 hr*ng/g.Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse kidney after a single 20 μg/kg intravenous dose.
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2015-12-03
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