A Rigorous Theoretical Framework for Non-Surgical Precision Management of Prostate Cancer: Hierarchical Fusion of Graph Attention Networks, Vision Transformers, and Reinforcement Learning with Provable PAC-Bayes Generalization, Lyapunov-Stable ODE Dynamics, and Spatiomolecular Reasoning for Adaptive Therapeutic Regimens
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Prostate cancer (PCa) exhibits profound spatiotemporal genomic and radiomic heterogeneity that invalidates static, unimodal clinical decision paradigms. This manuscript presents the \textbf{Prostate Precision Fusion Platform (PPFP)}---a \textbf{theoretically self-contained, mathematically complete conceptual framework}---for non-surgical management of localized disease and adaptive combination therapy design in metastatic castration-resistant prostate cancer (mCRPC). solved via Proximal Policy Optimization (PPO) with a transition function (Theorem~\ref{thm:picard}). (Theorem~\ref{thm:rademacher}). For mCRPC (Stratum B), we prove (Theorem~\ref{thm:ppo_monotone}). Global Sobol sensitivity analysis and a granular Monte Carlo parameter grid confirm high robustness (AUC variance $<0.02$ at 15\% additive Gaussian noise). The framework's generality is demonstrated by a \textbf{formal category-theoretic morphism} to HER2-enriched and triple-negative breast cancer. All derivations, proofs, simulations, and complete reproducible Python code are embedded herein to ensure \textbf{complete self-sufficiency, falsifiability, and internal consistency}.



