The effects of High fat feeding on plasma lipids in ApoF deficient mice.

Female ApoF wild type (WT), heterozygous (Het), and knockout (KO) mice were bled for baseline lipid measurements and placed on a diet containing 45% kcal from fat for 9 weeks. Plasma was then collected after 2, 4, and 9 weeks on the diet. All mice were fasted 4 hours before bleeding at every time point. Values are reported as the mean +/− standard deviation for each group (WT n = 8, Het n = 10, KO n = 8). Two Way ANOVA Results:Cholesterol: Time pHDL-C: Time pNon HDL-C: Time pTriglycerides: Time n.s.,Genotype p = 0.0025 (Bonferroni vs WT: * pCE: Interaction p = 0.0428, Time pFree Chol: Time p