ADH5 oxidises S-HMGSH to S-FGSH

Alcohol dehydrogenase class-3 (ADH5) is a cytosolic dimeric enzyme that binds 2 Zn2+ per subunit. It is very ineffective in oxidising ethanol, but it readily catalyses the oxidation of S-(hydroxymethyl) glutathione (S-HMGSH) to S-formylglutathione (S-FGSH) (Kaiser et al. 1988, Julia et al. 1988) as well as the oxidation of long-chain primary alcohols (not shown here).

乙醛脱氢酶类-3（ADH5）是一种胞浆二聚酶，每个亚基可结合2个Zn2+离子。其在氧化乙醇方面效率极低，然而却能有效地催化S-（羟甲基）谷胱甘肽（S-HMGSH）氧化为S-形式谷胱甘肽（S-FGSH）（Kaiser等人，1988年，Julia等人，1988年）以及长链伯醇的氧化（此处未展示）。