Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g
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Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g Descriptor: 4-azanyl-6-[[(1~{S})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION Authors: Whittington, D.A, Tang, J, Yakowec, P. Deposit date: 2016-06-01 Release date: 2017-06-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Discovery and in vivo evaluation of the potent and selective PI3K-delta inhibitors AM-0687 and AM-1430 To Be Published
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2016-06-01
