RNA-seq analyses of liver samples in mice fed normal diet or subject to 60% high fat diet for 23 weeks

To systemically identify the long non-coding RNAs(lncRNAs) expression profile in the liver, specifically those involved in lipid metabolism, we generated a hyperlipemia model in mice. The hyperlipemia protocol was as follows:mice post natal 4 weeks fed normal diet or subjet to 60% high fat diet for 23 weeks, the mice were immediately sacrificed for liver and plasma collection. In this study presented here,we separate mouse livers fed normal diet or subject to 60% high fat diet for 23 weeks and identified the genome-wide expression level of lncRNAs.