Runtime (h) of ML methods on alignments of the three largest biological datasets.

“Average” refers to the average across datasets. Some alignments were missing due to the inability of an alignment method to successfully align a dataset due to excessive memory requirements on datasets of this size, preventing ML methods from running; these entries are marked “n.d.”. “n.a.” denotes averages that were not computed due to missing entries. for values in columns other than the “Average” column. for the “Average” column.