The protective role of hydrogen sulfide and its impact on gene expression profiling in rat model of COPD. The protective role of hydrogen sulfide and its impact on gene expression profiling in rat model of COPD

To investigate the role of H2S in Chronic obstructive pulmonary disease (COPD), a rat model of COPD was established by cigarette smoking (CS) and intratracheal instillation of lipopolysaccharide (LPS). Rats were randomly divided into 4 groups: Control, CS+LPS, CS+LPS+NaHS and CS+LPS+propargylglycine (PPG). Transcription profiling of lung tissue comparing Control with CS+LPS, CS+LPS with CS+LPS+NaHS, and CS+LPS with CS+LPS+PPG. The goal was to determine the impact of H2S on gene expression profiling in rat model of COPD. Overall design: 4 groups, Control vs. CS+LPS; CS+LPS vs. CS+LPS+NaHS; CS+LPS vs. CS+LPS+PPG; each group has 3 replicates.