Table S1 - Age-Dependent Relevance of Endogenous 5-Lipoxygenase Derivatives in Anxiety-Like Behavior in Mice

In the Light-Dark Box task, MK-886 treatment induces anxiogenic-like behavior in aged mice, but not in 3-month-old nor in 5-LO knockout mice. After treatment with 5-LO inhibitors (MK-886 or Zileuton), adult (3 months) or aged (12 months) mice were tested in the Light-Dark box task. Three-month-old mice did not show altered anxiety-like behavior in response to either treatment, whereas 12-month-old mice displayed an anxiogenic-like behavior, as measured by reduced time spent in bright side and increased time spent in dark side. Adult 5-LO knockout mice (5-LO KO) did not show any difference in anxiety-like behavior compared to control mice. Data are presented as Mean ± SEM. *p (DOCX)