Correlating dynamical molecular behaviour with controlled anti-cancer drug release from zeolite H-ZSM5

Zeolites are crystalline porous materials ideal for use as drug delivery systems as they are sustainable, recyclable, and can house drug molecules of interest. We aim to perform the first QENS experiments probing the mobility of 5FU in H-ZSM-5 zeolites while varying the Si/Al ratio and therefore the Br�nsted acid density to determine its effect on drug mobility. We will study the mobility of 5FU in zeolites H-ZSM-5 (Si/Al = 15, 40 and 140) at body temperature (310 K). This will allow for both validation of classical molecular dynamics studies probing 5FU mobility in zeolites carried out so far, and for a detailed understanding of how framework characteristics such as Si/Al ratio affect molecular behaviour of 5FU, crucial for the design and optimisation of affordable and precisely controlled release dosage forms of anticancer drugs.