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Published Orthogonal Replication, Exact Response Algebra, and Dominant-Dual Gate-Bridge-Control Falsification Simplex of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#116, 2026-03-26)

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Zenodo2026-03-27 更新2026-05-26 收录
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This version fixes the next mechanistic milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#116 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, selectivity and explicit taxonomy of the analyzable published split-family background, strong-core switch decomposition, an arm-polarized fracture axis, flat-to-polarized amplification, cryptic stable hierarchy, top-arm conservation, dual-collapse taxonomy, permutation rigidity, exact three-term response algebra, and a final phase-83 falsification-simplex layer in which the target resolves into a quantitative gate-bridge-control rescue budget. Across 7 analyzable published exact split families, only the target TOP3A/RMI2/CCDC69 family realizes both a strict low > mid > high positive rescue-share order and a dominant-dual budget with more than 99% of positive rescue mass on the lower two stable-coordinate arms. Its exact positive rescue shares are RMI2 = 0.565209, TOP3A = 0.432949, and CCDC69 = 0.001842, while the only comparison strong-core family leaves all positive residue on the stable high arm. This package contains the milestone report, claim documents, phase reports, summary tables, family tables, source files, the fracture-aware generator source, and the earlier wet-lab/falsification documents that connect the response-algebra result to a direct experimental pass/fail budget. This is a computational discovery package and not a completed causal validation study.

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2026-03-27
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