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Epitope analysis by cross-blocking with anti-IGF-1R antibodies of known epitopes (continued).

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These data further narrow the epitope of hR1 to be between the amino acid residues 185 and 222 located in the mid-first half of the cysteine-rich domain. Note that mR1, cR1, and hR1 crossblock 24–60 and may allosterically inhibit the binding of MAB391.

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2012-08-31
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