CSF1R marks a subset of foetal LMPPs with Acute Myeloid Leukaemia propagation properties in a KMT2A-MLLT3 mouse model
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As KMT2A-MLLT3 oncoprotein can give rise to ALL and AML in infants, we investigated whether such choice could lie in two subsets of foetal LMPPs, that express or not CSF1R, and found that CSF1R mark a more potent subpopulation with leukaemic-initiating Overall design: Murine CSF1R+/-LMPPs (Lin- Sca1+ ckit+ CD45+ Flt3+CSF1R+/-) were sorted from KMT2AMLLT3-expressing E14.5 foetal livers. Cell populations were analysed by bulk RNA-Seq
创建时间：
2026-02-25
