Additional file 1 of Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals

Additional file 1: Supp. Tables S1 to S10. Table S1. Initial screening of hearing loss genes (n = 420) for signatures of coding positive selection in the mammalian basal branch. Table S2. Extensive analysis of 58 candidate positively selected hearing loss genes obtained from initial screening. Table S3. Screening of coding positive selection in the human branch, using a background of primate species for our hearing loss database (n = 420). Table S4. Screening of non-coding acceleration in the mammalian and human branches. Table S5. Functional evidence of regulatory activity in non-coding accelerated elements in the mammalian and human branches. Table S6. Effect of variation in positively selected sites using human protein as reference. Table S7. Gene ontology analyses for mammal coding positive selected genes against the hearing loss database. Table S8. Gene ontology analyses for different sets of genes: non-coding elements in mammals (ncTSARs) vs. coding positive selection in mammals. Table S9. Information for candidate regulatory regions in hearing loss genes tested in enhancer assays in transgenic zebrafish. Table S10. Summary of distinct approaches performed to test the relative contribution of coding and non-coding elements for each hearing loss gene.