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A Facile Route to Polysubstituted<i> N</i>-Benzyl Pyroglutamates

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NIAID Data Ecosystem2026-03-06 收录
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Base-induced coupling/cyclization reactions of α-sulfonylacetamide with various ethyl (Z)-2-bromo-2-propenoates have been carried out. The polysubstituted pyroglutamate carbon skeleton, with three contiguous asymmetric centers, was built up in one step. A ring-closure mechanism is proposed for the reactions.

创建时间:
2016-08-20
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