Crystal structure of SARS-CoV-2 Mpro with compound 5
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Crystal structure of SARS-CoV-2 Mpro with compound 5 Descriptor: (2~{R})-3-(4-chlorophenyl)-2-[2-[(2~{R})-1-isoquinolin-4-ylcarbonylpyrrolidin-2-yl]ethanoyl-methyl-amino]-~{N}-methyl-propanamide, 3C-like proteinase nsp5 Authors: Prasad, A, Schmitt, A, Preuss, F, Maskos, K, Wang, X, Gotchev, D, Konz Makino, D.L. Deposit date: 2024-08-19 Release date: 2024-11-06 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.476 Å) Cite: Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants. J.Med.Chem., 67, 2024
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2024-08-19
