Figure 4 D Effect of CMC 2.24 on MMP 2 activity in the BALFs.xlsx

demonstrate the significant increase in MMP-2 activity in COPD mice (COPD vs control, P&lt;0.01) and PM 2.5-exposed mice (COPD plus PM2.5 exposure vs COPD, P&lt;0.05). The levels of MMP-9 and MMP-2 remain normal in COPD mice exposed to PM2.5 when treated with CMC 2.24. These results demonstrate that CMC 2.24 treatment essentially reduces these excessive levels back down to healthy “control” levels under circumstances where MMP-2 and 9 levels had been increased by COPD or by COPD exacerbated by a PM2.5 challenge. <br>