Cryo-EM structure of human p97 bound to CB-5083 and ATPgS.
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Cryo-EM structure of human p97 bound to CB-5083 and ATPgS. Descriptor: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. Deposit date: 2021-07-23 Release date: 2021-09-22 Last modified: 2025-06-11 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297, 2021
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2021-07-23
