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Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

NIAID Data Ecosystem2026-05-01 收录

细菌耐药性机制

药物靶点解析

数据链接：

https://www.rcsb.org/structure/2J8S 数据链接链接失效反馈

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资源简介：

Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

应用场景：

创建时间：

2023-12-13

细菌耐药性机制

细菌转录组学

RNA-Seq on common bacterial pathogens in the presence vs absence of a variety of antibiotics. Two susceptible and two resistant isolates were exposed to antibiotics in laboratory culture, total RNA wa

NIAID Data Ecosystem40

W228S-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1

细菌耐药性机制

金属β-内酰胺酶功能研究

W228S-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1

NIAID Data Ecosystem10

Chemogenomic screen for imipenem resistance in Gram-negative bacteria (WT)

细菌耐药性机制

化学基因组学

Carbapenem-resistant Gram-negative bacteria are considered as a major threat to global health. Imipenem (IMP) is used as a last line of treatment against these pathogens but its efficiency is diminish

NIAID Data Ecosystem00

Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

细菌耐药性机制

细菌代谢干预治疗

Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

integrated proteome resources30

Pairwise distance in Å between catalytic residues in Class A β-lactamases – Ser70(a), Lys73(b), Ser130(c), [Arg/Lys]234(d), Glu166(e).

β-内酰胺酶催化残基距离

细菌耐药性机制

Pairwise distance in Å between catalytic residues in Class A β-lactamases – Ser70(a), Lys73(b), Ser130(c), [Arg/Lys]234(d), Glu166(e).

NIAID Data Ecosystem10