The goal of this dataset was to use RNA-seq in human heart tissue to delineate etiology-specific gene expression signatures in heart failure. We performed poly-A enriched RNA-seq in 64 samples from hu
G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genet
COL I : collagen type I, COL III: collagen type III, α-MHC: alpha-myosin heavy chain, β-MHC: beta-myosin heavy chain, SERCA2A: sarco/endoplasmatic reticulum calcium ATPase, GLUT1: glucose transporter
Renal insufficiency is a risk factor for development of cardiovascular disease. In this study our aim was to investigate functional and structural changes in the heart of dogs with mild renal insuffic
Heart failure is a leading cause of cardiovascular mortality with limited options for treatment. We analyzed whether the anti-ischemic drug ranolazine could retard the progression of heart failure in
