Annexin-A1-mediated regulation of the efferocytosis in tumor-associated macrophage promotes anti-tumor immune response by activating the cGAS/STING pathway in pancreatic cancer

To explore the mechanism of macrophage Anxa1 deficiency to induce anti-tumor responses, we preformed RNA sequencing of pancreatic tumors from Anxa1ΔMɸ and Anxa1WT mice. Panc02 cells were subcutaneously implanted into Anxa1flox/flox and Anxa1ΔMɸ mice. After 4 weeks, the mice were sacrificed and the tumors were obtained for RNA sequence.