Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation. Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

We report a bulk transcriptomic dataset of mouse dorsal hippocampus to identify gene expression changes of spatial object recognition training. We report a spatial transcriptomics dataset of mouse brain tissue generated with the 10x Genomics Visium platform to identify gene expression profiles of spatial object recognition training. We report a single nuclei ATAC-seq and a Single nuclei RNA-sequencing using SPLiT-pool barcoding datasets of mouse dorsal hippocampus to identify chromatin and gene expression changes of spatial object recognition training. Overall design: We performed bulk sequencing gene expression analysis from dorsal hippocampus of 2 groups (trained spatial object recognition vs. home cage). We performed spatial gene expression profiling analysis using Visium data obtained from coronal mouse brain sections of 2 groups (trained spatial object recognition vs. home cage). We performed single nuclei ATAC-seq and a Single nuclei RNA-sequencing using SPLiT-pool barcoding from dorsal hippocampus of 2 groups (trained spatial object recognition vs. home cage).