Lung cancer model using bioengineered rat lungs

This study describes the development of a successful ex vivo lung cancer model based on bioengineered lungs. Specifically, we show that decellularization of rat lungs, followed by recellularization with various non-cancerous cell types and human lung cancer cell lines results in a 3-D model morphologically and physiologically similar to in vivo lung cancer. We used A549 cells for RNA-seq analysis.