Receptive field area_nyxnob.xlsx

Abstract: Patients with congenital nystagmus, unvoluntary eye movements, often
have a reduced visual acuity. Some of these patients have a retinal-specific
mutation in the protein nyctalopin, which is also present in the Nyxnob mouse. In these mice,
retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded
axonal projections towards the dLGN and consequently to a desegregation of
retinal projections to the brain [1]. In this study, we investigate whether the
receptive fields of Nyxnob
RGCs have also expanded by measuring the size of their receptive fields using
MEA recordings.

Contrary to our
expectation, relative to wild-type (WT) mice we found receptive field sizes in
the Nyxnob retina had not
increased but instead had decreased for green-light preferring RGCs.
Additionally, we also found the receptive fields of UV-light preferring RGCs
are larger than green-light preferring RGCs in both WT and Nyxnob mouse.