Effect size and significance of association for SNPs associated with disease.

Data shown are for aeQTL mapping in the combined population. Effects are reported as fold changes in expression for individuals who are homozygous for the minor allele relative to individuals who are homozygous for the major allele (calculated from allelic expression data using two transcribed SNPs per gene). Association for each SNP is presented as the −log10 P-value and the −log10 of the family wise error rate (FWER) using a Bonferroni correction for the 56 SNPs tested. Associations that were significant using a FWER threshold of 0.05 (corresponding to −log10P of 3.05, or −log10FWER of 1.3) were regarded as significant.