GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp
本数据集为《Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism》论文的补充数据,包含2个Excel文件。数据基于GEO数据库的肌管和骨骼肌组织公开数据,经RMA归一化、同源基因匹配及基因符号聚合处理,用于揭示不同骨骼肌模型的转录组与代谢异质性。 论
To uncover the molecular mechanisms that underlie the effects of mutant p97 on human MNs and search for potential treatments, we differentiated iPSCs derived from IBMPFD patients. These cells, which c