Identified cis-mQTLs/eQTLs where methylation of CpG sites is a potential mediator of genetic association with mRNA expression in human pancreatic islets.
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Causal Inference Test (CIT) was used to test if associations between SNPs identified in the cis-mQTL analysis and islet mRNA expression was mediated by DNA methylation of CpG sites.G vs M: Adjusted associations between genotype (G) and DNA methylation (M) – cis-mQTL analysis. P-values corrected for multiple testing based on the number of independent tests performed.G vs E: Adjusted associations between genotype (G) and human islet mRNA expression (E) – eQTL analysis of cis-mQTL-SNPs. P-values corrected for multiple testing based on the number of independent tests performed.CIT: Causal hypothesis at 5% FDR (Q-valueIdentified cis-mQTLs/eQTLs where methylation of CpG sites is a potential mediator of genetic association with mRNA expression in human pancreatic islets.
