Direct Conversion of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
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Direct Conversion of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
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创建时间：
2010-11-12
相关数据集
The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]. The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how the cytokine is regulated and if it plays a role during embryo development r
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Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]
Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil
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Additional file 6: of Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency
Table S2. Gene ontology analysis from downregulated gene sets in Sirt6-null iPS-like cells. (XLSX 41 kb)
Figshare2024-02-14 更新30
Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens
Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu
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α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition
In early mouse embryogenesis, the distinct enrichment of α-ketoglutarate (αKG) in blastocysts and L-2-hydroxyglutarate (L-2HG) in 2-cell (2C) embryos serves as a key metabolic signature. While elevate
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