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Spatiotemporal resolving Crohn's disease fibrosis

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP533079
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Crohn's disease is a chronic inflammatory disease of the bowel often complicated by fibrotic strictures that require invasive treatments including surgery. The mechanisms underlying intestinal fibrosis are not defined yet, and specific treatments are missing. Here we employed spatial transcriptomics to track the cellular and molecular evolution from healthy intestine to fibrosis in patients with Crohn's disease. Overall design: n=2 10x Visium slides containing tissue composites
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2025-09-25
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